研究成果 – 久恒研究室

2024

Li, H., Tamura, R., Hayashi, D., Asai, H., Koga, J., Ando, S., Yokota, S., Kaneko, J., Sakurai, K., Sumiyoshi, A., Yamamoto, T., Hikishima, K., Tanaka, K., Mchugh, T., Hisatsune, T. (2024) Silencing dentate newborn neurons alters excitatory/inhibitory balance and impairs behavioral inhibition and flexibility. Science Advances, Vol 10, Issue 2, DOI: 10.1126/sciadv.adk4741

Luo, S., Tamada, A., Saikawa, Y., Wang, Y., Yu, Q., Hisatsune, T. (2024) P2Y1R silencing in Astrocytes Protected Neuroinflammation and Cognitive Decline in a Mouse Model of Alzheimer’s Disease. Aging and Disease, 15, doi.org/10.14336/AD.2023.1006

2023

Sakurai, K., Okada, E., Anzai, S., Tamura, R., Shiraishi, I., Inamura, N., Kobayashi, S., Sato, M., Matsumoto, T., Kudo, K., Sugawara, Y., Hisatsune, T. (2023) Protein-Balanced Dietary Habits Benefit Cognitive Function in Japanese Older Adults . Nutrients, 15(3), 770 . doi.org/10.3390/nu15030770

Kao, K.-C., Hisatsune, T.* (2020) Differential effects of dopamine D1-like and D2-like receptor agonists on water drinking behavior under thirsty conditions in mice with reduced dopamine secretion. European Journal of Neuroscience 51, 584-597 doi.org/10.1111/ejn.14568

2019

Masuoka, N., Yoshimine, C., Hori, M., Tanaka, M., Asada, T., Abe, K., Hisatsune, T.* (2019) Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4. Nutrients 11, 1626; doi:10.3390/nu11071626

2018

21st US-Japan Cellular and
Gene Therapy Conferenceでの発表スライド

Ding, Q., Tanigawa, K., Kaneko, J., Totsuka, M., Katakura Y., Imabayashi, E., Matsuda, H., Hisatsune, T.(2018)Anserine/carnosine supplementation preserves blood flow in the prefrontal brain of elderly people carrying APOE e4. Aging and Disease, 9, 334-335. doi.org/10.14336/AD.2017.0130.

2017

Chen, S. C-J, Abe, Y., Fang, P-T., Hsieh, Y-J., Yang, Y-I., Lu, T-Y., Oda, S., Mitani, H., Lian, S-L., Tyan, Y-C., Huang, C-J., Hisatsune,T. Prognosis of Hippocampal Function after Sub-lethal Irradiation Brain Injury in Patients with Nasopharyngeal Carcinoma. Scientific Reports, DOI: 10.1038/s41598-017-13972-2.

Katakura, Y., Totsuka, M., Imabayashi, E., Matsuda, H., Hisatsune, T.Anserine/Carnosine Supplementation Suppresses the Expression of the Inflammatory Chemokine CCL24 in Peripheral Blood Mononuclear Cells from Elderly People. Nutrients, 9, 1199; DOI: 10.3390/nu9111199.

Kaneko, J., Enya, A., Enomoto, K., Ding, Q., Hisatsune, T.Anserine (beta-alanyl-3-methyl-L-histidine) improves neurovascular-unit dysfunction and spatial memory in aged AβPPswe/PSEN1dE9 Alzheimer’s-model mice. Scientific Reports, DOI: 10.1038/s41598-017-12785-7.

Matsuda, T., Hisatsune, T.Cholinergic modification of neurogenesis and gliosis improves the memory of AβPPswe/PSEN1dE9 Alzheimer’s model mice fed a high-fat diet. Journal of Alzheimer’s Disease, 56, 1-23.

2016

Hisatsune, T.*, Kaneko, J., Kurashige, H., Cao, Y., Satsu, H., Totsuka, M., Katakura, Y., Imabayashi, E. and Matsuda, H. Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People. Journal of Alzheimer’s Disease, 50, 149-159.(2016)

2015

Yang, Y.-I., Lu, T.-Y., Chiu, Y.-Y., Chang, C.-C., Lai, J.-J., Huang, C.-J., Lian, S.-L., Hisatsune, T., Wan, Y.-T., Hong, Y.-J., Chen, S. C.-J.* Using fMRI to evaluate working memory differences in cognitive function of NPC patients before and after radiotherapy Chinese Journal of Radiologic Technology, 39(3), 121-129.(2015)

Rokicki, J., Li, L., Imabayashi, E., Kaneko, J., Hisatsune, T. and Matsuda, H.* Daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults. Frontiers in Aging Neuroscience, 7, 219 (11 pages),(2015)

2014

“鶏肉のイミダゾールジペプチドの脳老化改善効果を発見-鶏肉摂取を介した認知症予防の取組に道を拓く-“＜2014年農林水産研究成果10大トピックス＞に選ばれました。　　　

Hisatsune, T. (2014). 超高磁場MRI研究開発の最前線(Research and development of Ultra High Field MRI) Magnetics Jpn 9, 180-186.

“肉類ペプチドに脳萎縮抑制効果・神経心理機能強化の可能性” プレスリリースの内容

2013

Haishi, T., Abe, Y., Togashi, K., Kose, K., and Hisatsune, T. (2013). Live mice imaging with a 14.1T narrow-bore NMR magnet heading for fMRI by using an independent digital console and gradient probe. 12th International Conference on Magnetic Resonance Microscopy, p82.

Herculano B; Tamura M; Ohba A; Shimatani M; Kutsuna N; Hisatsune T “β-Alanyl-L- Histidine Rescues Congnitive Deficits Caused by Feeding a High Fat Diet in a Transgenic Mouse Model of Alzheimer’s Disease” Jounal of Alzheimer’s Disease 33, 983-997(2013) 　　　

Nochi, R; Kaneko, J; Okada, N; Terazono, Y; Matani, A; Hisatsune, T “Diazepam treatment blocks the elevation of hippocampal activity and the accelerated proliferation of hippocampal neural stem cell after focal cerebral ischemia in mice” J. Neurosci. Res., DOI: 10.1002/jnr.23264

Chin Y; Kishi M; Sekino M; Nakajo F; Abe Y; Terazono Y; Ohsaki H; Kato F; Koizumi S; Gachet C; Hisatsune T “Involvement of glial P2Y1 receptors in cognitive deficit after focal cerebral stroke in a rodent model ” J. Nueroinflammation, 2013, 10:95

2012

Abe Y, Sekino M, Terazono Y, Ohsaki H, Fukazawa Y, Sakai S, Yawo, Hisatsune T.
“Opto-fMRI analysis for exploring the neuronal connectivity of the hippocampal formation in rats.” Neuroscience Research, 74, 248-255(2012)

Nochi R, Kato T, Kaneko J; Itou Y; Kuribayashi H; Fukuda S; Terazono Y; Matani A; Kanatani S; Nakajima K; Hisatsune T “Involvement of mGluR5-signaling in activity-related proliferation of adult hippocampal neural stem cells” Eur. J. Neurosci., 36, 2273-2283(2012)

Abe Y; Sekino M; Fukazawa Y; Yawo H; Ohsaki H; Hisatsune T “Functional analysis of the hippocampus using opto-fMRI” in the post-conference proceeding of ICCN2011 Niseko (June 9-13, 2011; The 3rd International Conference on Cognitive Neurodynamics) “Advances in Cognitive Neurodynamics (III)” Springer 4 pages (2012)

2011

Herculano BA; Tamura M; Ohba A; Shimatani M; Kutsuna N; Hisatsune T “Carnosine (beta-alanyl-L-histidine) Treatment Ameliorates Memory Deficits Caused by High-Fat Diet in APPswe/PSEN1dE9 Mice” アルツハイマー病学会でのポスター発表. 記者発表の内容

Hisatsune T; Ide Y; Nochi R “Activity-dependent regulation of the early phase of adult hippocampal neurogenesis” in T. Seki et al. (eds.), Neurogenesis in the Adult Brain, Springer p. 217-236. (2011)

Sekino M; Miyazoe A; Ohsaki H; Hisatsune T; Ozaki O; Kiyoshi T; Wada H “MRI using a superconducting magnet with an off-centered homogeneous field zone” Journal of Applied Physics, 109, pp. 07D335 (2011)

Aizawa K; Ageyama N; Terao K; Hisatsune T “Primate-specific alterations in neural stem/progenitor cells in the aged hippocampus” Neurobiology of Aging, 32, 140-150 (2011) 記者発表の内容

Itou Y; Nochi R; Kuribayashi H; Saito Y; Hisatsune T; “Cholinergic activation of hippocampal neural stem cells in aged dentate gyrus” Hippocampus, 21, 446-459 (2011) 記者発表の内容

2010

Wada H; Sekino M; Ohsaki H; Hisatsune T; Ikehira H; Kiyoshi T “Prospect of High-Field MRI” IEEE Transactions on Applied Superconductivity, 20, 115-122 (2010)

Sekino M; Ohsaki H; Wada H; Hisatsune T; Ozaki O; Kiyoshi T “Fabrication of an MRI model magnet with an off-centered distribution of homogeneous magnetic field zone” IEEE Transactions on Applied Superconductivity, 20, 781-785 (2010)

Chin Y; Sato Y; Mase M; Kato T; Herculano B; Sekino M; Ohsaki H; Ageyama N; Ono F; Terao K; Yoshikawa Y; Hisatsune T;
“Transient decrease in cerebral motor pathway fractional anisotropy after focal ischemic stroke in monkey.” Neuroscience Research, 66, 406-411 (2010)

2009

Tanaka Y; Tozuka Y; Takata T; Shimazu N; Matsumura N; Ohta A; Hisatsune T “Excitatory GABAergic Activation of Cortical Dividing Glial Cells” Cerebral Cortex 19, 2181-2195 (2009)

Aizawa K; Ageyama N; Yokoyama C; Hisatsune T “Age-dependent alteration in hippocampal neurogenesis correlates with learning performance of macaque monkeys” Exp Animals, 58, 403-407 (2009)

Sato Y; Chin Y; Kato T; Tanaka Y; Tozuka Y; Mase M; Ageyama N; Ono F; Terao K; Yoshikawa Y; Hisatsune T “White matter activated glial cells produce BDNF in a stroke model of monkeys” Neuroscience Research, 65, 71-78 (2009)

2008

Ide Y; Fujiyama F; Okamoto-Furuta K; Tamamaki N; Kaneko T; Hisatsune T “Rapid integration of young newborn dentate gyrus granule cells in the adult hippocampal circuitry” European Journal of Neuroscience, 28, 2381-2392 (2008)

2007

2006

Koketsu D; Furuichi Y; Maeda M; Matsuoka N; Miyamoto Y; Hisatsune T “Increased number of new neurons in the olfactory bulb and hippocampus of adult non-human primates after focal ischemia” Experimental Neurology, 199, 92-102 (2006)

2005

Tozuka Y; Fukuda S; Namba T; Seki T; Hisatsune T “GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells” Neuron, 47, 803-815 (2005) Detailed information

Muramatsu D; Sato Y; Hishiyama S; Miyamoto Y; Hisatsune T “Transplantation of GABAergic neurons into adult mouse neocortex” Experimental Neurology, 194, 1-11 (2005)

Imura T; Kanatani S; Fukuda S; Miyamoto Y; Hisatsune T “Layer-specific production of nitric oxide during cortical circuit formation in postnatal mouse brain” Cerebral Cortex, 15, 332-340 (2005)

2004

Yoshida M; Fukuda S; Tozuka Y; Miyamoto Y; Hisatsune T “Developmental shift in bidirectional functions of taurine-sensitive chloride channels during cortical circuit formation in postnatal mouse brain” Journal of Neurobiology, 60, 166-175 (2004)

Sato Y; Koketsu D; Ageyama N; Ono F; Miyamoto Y; Hisatsune T “Successful retrograde transport of fluorescent latex nanospheres in the cerebral cortex of the Macaque Monkey” Experimental Animals, 53, 383-386 (2004)

2003

Yoshida N; Hishiyama S; Yamaguchi M; Hashiguchi M; Miyamoto Y; Kaminogawa S; Hisatsune T “Decrease in expression of α5 β1 integrin during neuronal differentiation of cortical progenitor cells” Experimental Cell Research, 287, 262-271 (2003)

Okada H; Miyakawa N; Mori H; Mishina M; Miyamoto Y; Hisatsune T “NMDA receptors in cortical development are essential for the generation of coordinated increases in [Ca2+]i in ‘Neuronal Domains’” Cerebral Cortex, 13, 749-757 (2003)

Koketsu D; Mikami A; Miyamoto Y; Hisatsune T “Nonrenewal of neurons in the cerebral neocortex of adult Macaque monkeys” Journal of Neuroscience, 23, 937-942 (2003)

Fukuda S; Kato F; Tozuka Y; Yamaguchi M; Miyamoto Y; Hisatsune T “Two distinct subpopulations of nestin-positive cells in adult mouse dentate gyrus” Journal of Neuroscience, 23, 9357-9366 (2003)

Matsumura N; Yoshida N; Ohota A; Miyamoto Y; Hisatsune T “Neural precursor cells from adult mouse cerebral cortex differentiate into both neurons and oligodendrocytes” Cytotechnology, 43, 19-25 (2003)

2002

Kaji T; Kaieda I; Hisatsune T; Kaminogawa S “SIN-1 induced p53-dependent apoptosis of murine primary neural cells: a critical role for p21ras-MAPK-P19 ARF pathway” Nitric Oxide, 6, 125-134 (2002)

Miyakawa N; Uchino S; Yamashita T; Okada H; Nakamura T; Kaminogawa S; Miyamoto Y; Hisatsune T “A glycine receptor antagonist, strychnine, blocked NMDA receptor activation in the neonatal mouse neocortex” Neuroreport, 13, 1667-1673 (2002)