About our Research 

The Video at the public Symposium “Aging Control Design for the 100-year life” Dr. Hisatsune gave a lecture at the University of Tokyo. (YouTube, 2023)

The Video at Endowed Chairs Symposium “Mechanisms of learning and memory lessoned from mice” Dr. Hisatsune gave a lecture at the University of Tokyo. (YouTube, 2023)

The Video at the public Symposium “Aging Design for 100 Years of Life” Dr. Hisatsune gave a lecture at the University of Tokyo. (YouTube, 2022)

Slides at “21st US-Japan Cellular and
                            Gene Therapy Conference” (PDF)

Research results have been published.

Li, H., Tamura, R., Hayashi, D., Asai, H., Koga, J., Ando, S., Yokota, S., Kaneko, J., Sakurai, K., Sumiyoshi, A., Yamamoto, T., Hikishima, K., Tanaka, K., Mchugh, T., Hisatsune, T. (2024) Silencing dentate newborn neurons alters excitatory/inhibitory balance and impairs behavioral inhibition and flexibility. Science Advances, Vol 10, Issue 2, DOI: 10.1126/sciadv.adk4741

Luo, S., Tamada, A., Saikawa, Y., Wang, Y., Yu, Q., Hisatsune, T. (2024) P2Y1R silencing in Astrocytes Protected Neuroinflammation and Cognitive Decline in a Mouse Model of Alzheimer’s Disease. Aging and Disease, 15,

Sakurai, K., Okada, E., Anzai, S., Tamura, R., Shiraishi, I., Inamura, N., Kobayashi, S., Sato, M., Matsumoto, T., Kudo, K., Sugawara, Y., Hisatsune, T. (2023) Protein-Balanced Dietary Habits Benefit Cognitive Function in Japanese Older Adults . Nutrients, 15(3), 770.

Masuoka, N., Lei, C., Li, H., Inamura, N., Shiotani, S., Yanai, N., Sato, K., Sakurai, K., Hisateune, T. (2021) Anserine, HClO-scavenger, protected against cognitive decline in individuals with mild cognitive impairment. AGING, 13.

Sakurai, K., Shen, C., Shiraishi, I., Inamura, N., Hisatsune, T. (2021) Consumption of Oleic Acid on the Preservation of Cognitive Functions in Japanese Elderly Individuals. Nutrients, 13, 284.

Sakurai, K., Li, H., Inamura, N., Masuoka, N., Hisateune, T. (2020) Relationship between elevated impulsivity and cognitive declines in elderly community‑dwelling individuals. Scientific Reports, 10, 21032.

Sakurai, K., Shen, C., Ezaki, Y., Inamura, N., Fukushima, Y., Masuoka, N., Hisatsune, T. (2020) Effects of Matcha Green Tea Powder on Cognitive
Functions of Community-Dwelling Elderly
Individuals. Nutrients, 12, 3639; doi:10.3390/nu12123639

Sakurai, K., Shintani, T., Jomura, N., Matsuda, T., Sumiyoshi, A., Hisatsune, T.* (2020) Hyper BOLD Activation in Dorsal Raphe Nucleus of APP/PS1 Alzheimer’s Disease Mouse during Reward-Oriented Drinking Test under Thirsty Conditions. Scientific Reports, 10, 3915. SREP-19-36247, online (2020.3.3)*

*Press release (in Japanese)

Kao, K.-C., Hisatsune, T.* (2020) Differential effects of dopamine D1-like and D2-like receptor agonists on water drinking behavior under thirsty conditions in mice with reduced dopamine secretion. European Journal of Neuroscience 51, 584-597

Masuoka, N., Yoshimine, C., Hori, M., Tanaka, M., Asada, T., Abe, K., Hisatsune, T.* (2019) Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4. Nutrients 11, 1626; doi:10.3390/nu11071626